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The 1% concentration range used in most published clinical trials sits at the level demonstrated to produce dermal effects while maintaining a formulation viscosity optimized for absorption
doi: 10.1007/s13577-020-00419-6 246 WangJKongXHuHShiS
Additionally, its effects on gut motility and bowel function mean it warrants caution in patients with bowel obstruction or severe gastrointestinal surgery history
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Erstmals beschrieben und isoliert wurde es 1993 von dem kroatischen Forscher Predrag Sikiri und Kollegen an der Universitt Zagreb aus einem Protein des menschlichen Magensafts (Jzwiak et al., Pharmaceuticals 2025)
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